{"id":54050,"date":"2021-05-09T19:27:53","date_gmt":"2021-05-09T16:27:53","guid":{"rendered":"https:\/\/www.bghaber.org\/bghaber\/?p=54050"},"modified":"2021-05-23T12:44:01","modified_gmt":"2021-05-23T09:44:01","slug":"prof-dr-nesrin-ozoren-ve-ekibi-kovid-19-asisinda-hayvan-deneyi-asamasina-gecti","status":"publish","type":"post","link":"https:\/\/www.bghaber.org\/bghaber\/prof-dr-nesrin-ozoren-ve-ekibi-kovid-19-asisinda-hayvan-deneyi-asamasina-gecti\/","title":{"rendered":"Prof. Dr. Nesrin \u00d6z\u00f6ren ve ekibi Kovid-19 a\u015f\u0131s\u0131nda hayvan deneyi a\u015famas\u0131na ge\u00e7ti"},"content":{"rendered":"
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Sanayi ve Teknoloji Bakanl\u0131\u011f\u0131 ile T\u00dcB\u0130TAK koordinasyonunda olu\u015fturulan yeni tip koronavir\u00fcs (Kovid-19) a\u015f\u0131 \u00e7al\u0131\u015fma gruplar\u0131 aras\u0131nda yer alan Prof. Dr. Nesrin \u00d6z\u00f6ren ve ekibi, Bo\u011fazi\u00e7i \u00dcniversitesi Molek\u00fcler Biyoloji ve Genetik B\u00f6l\u00fcm\u00fc Laboratuvar\u0131’nda y\u00fcr\u00fct\u00fclen a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131nda hayvan deneyi a\u015famas\u0131na ge\u00e7ti. \u00d6z\u00f6ren, a\u015f\u0131 geli\u015ftirme konusunda gelinen noktay\u0131 Anadolu Ajans\u0131\u2019na verdi\u011fi s\u00f6yle\u015fide kamuoyu ile payla\u015ft\u0131. S\u00f6yle\u015fiden dikkat \u00e7ekici ba\u015fl\u0131klar\u0131 Bo\u011fazi\u00e7i\u2019nden Haberler i\u00e7in derledik.<\/div>\n
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Sanayi ve Teknoloji Bakanl\u0131\u011f\u0131 ile T\u00dcB\u0130TAK koordinasyonunda Kovid-19 a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131 i\u00e7in olu\u015fturulan sekiz ara\u015ft\u0131rma grubu aras\u0131nda yer alan Prof. Dr. Nesrin \u00d6z\u00f6ren ve ekibi laboratuvar ortam\u0131nda y\u00fcr\u00fctt\u00fckleri \u00e7al\u0131\u015fmalar\u0131 Anadolu Ajans\u0131\u2019ndan\u00a0Anda\u00e7 Hongur\u00a0<\/strong>ile payla\u015ft\u0131. Nisan ay\u0131ndan bu yana a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131 Bo\u011fazi\u00e7i \u00dcniversitesi Molek\u00fcler Biyoloji ve Genetik B\u00f6l\u00fcm Ba\u015fkan\u0131 Prof. Dr. Nesrin \u00d6z\u00f6ren’in koordinasyonunda s\u00fcrd\u00fcren; Dr. \u00d6\u011fretim \u00dcyesi Tolga S\u00fctl\u00fc’n\u00fcn ve \u0130T\u00dc Molek\u00fcler Biyoloji ve Genetik B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Prof. Dr. Gizem Dinler Do\u011fanay’\u0131n tak\u0131mlar\u0131ndan olu\u015fan 15 ki\u015filik ekip Bo\u011fazi\u00e7i \u00dcniversitesi\u2019nde geli\u015ftirilen, d\u00fcnyan\u0131n 4 b\u00f6lgesinde patentli, T\u00fcrkiye’nin ilk ve tek biyoteknoloji bulu\u015fu olan mikrok\u00fcrecik teknolojisi \u00fczerinden \u00e7al\u0131\u015fmalar\u0131n\u0131 s\u00fcrd\u00fcr\u00fcyor. Bu teknoloji ayn\u0131 zamanda protein yap\u0131lar\u0131n\u0131n \u00f6zelli\u011finden dolay\u0131 bozulmayan a\u015f\u0131 teknolojisi olarak biliniyor.<\/p>\n

Anadolu Ajans\u0131\u2019n\u0131n 29 A\u011fustos tarihinde payla\u015ft\u0131\u011f\u0131 haberde Prof. Dr. Nesrin \u00d6z\u00f6ren a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131n de\u011fi\u015fik teknolojilerle yap\u0131ld\u0131\u011f\u0131na de\u011finirken, vir\u00fcs\u00fc hastadan izole ederek safla\u015ft\u0131r\u0131p, laboratuvar k\u00fclt\u00fcr\u00fc ortam\u0131nda b\u00fcy\u00fct\u00fcp, kimyasalla veya radyoaktiviteyle inaktive edip, inaktif a\u015f\u0131 yapman\u0131n, en eski ve en k\u0131sa yoldan yap\u0131lan \u00e7al\u0131\u015fmalar oldu\u011funu anlatt\u0131.<\/p>\n

Yeni molek\u00fcler biyoloji teknikleriyle rekombinant (rDNA) a\u015f\u0131lar devrine ge\u00e7ildi\u011fini vurgulayan \u00d6z\u00f6ren, a\u015f\u0131 a\u015famalar\u0131 hakk\u0131nda \u015fu bilgileri verdi:<\/p>\n

“Bir vir\u00fcs\u00fcn veya bir mikrobun insan v\u00fccut ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131n\u0131 en iyi tetikleyen par\u00e7as\u0131n\u0131 sadece \u00e7o\u011falarak, uygun tampon \u00e7\u00f6zelti ve koruyucu gerekirse koruyucuyla birle\u015ftirip \u015fi\u015feleme gerekiyor. Biz, h\u00fccre deneylerinde o yap\u0131lara, ‘Rekombinant proteinler d\u00fczg\u00fcn olmu\u015f mu?’ diye bak\u0131yoruz, gerekirse h\u00fccre tabanl\u0131 deneylerde ‘A\u015f\u0131lar uygun cevap veriyor mu?’ diye test ediyoruz. Sonraki a\u015famada \u00f6ncelikle fare deneyleri s\u00f6z konusu. Burada da ‘Verdi\u011fimiz a\u015f\u0131, farede ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131n\u0131 tetikledi mi?’ sorusunun cevaplanmas\u0131 gerekiyor. \u0130stiyoruz ki fareler hem sa\u011fl\u0131kl\u0131 kals\u0131n deney s\u00fcrecinde hem de belirli seviyede ba\u011f\u0131\u015f\u0131klama olsun. Fare deneylerinde olumlu tespitler olursa daha sonra canl\u0131 vir\u00fcsle tekrar etme deneyi yap\u0131l\u0131yor. Buna da challenge deneyi deniliyor. A\u015f\u0131y\u0131 uyguluyorsunuz sonra mikrobun canl\u0131s\u0131n\u0131 veriyorsunuz. Burada da \u00f6rne\u011fin korona vir\u00fcs\u00fcn\u00fc geri verdik ve vir\u00fcs \u00e7o\u011falamad\u0131ysa akci\u011ferde, bu harika bir haber\u2019\u2019.<\/strong><\/p>\n

\u00d6z\u00f6ren, klinik \u00f6ncesi \u00e7al\u0131\u015fmalar\u0131n tamamlanmas\u0131n\u0131n ard\u0131ndan insana uygulama yapabilmek i\u00e7in T\u00fcrk \u0130la\u00e7 ve T\u0131bbi Cihaz Kurumundan prosed\u00fcrel onay ve etik kurul onay\u0131 gerekti\u011fini belirterek,\u00a0“T\u00fcrkiye’de Faz-1 deney yap\u0131labilecek 3-4 merkez son y\u0131llarda olu\u015fturuldu.”\u00a0<\/strong>dedi.<\/p>